Roflumilast topical

Generic name: roflumilast topical [ roe-FLUE-mi-last ]
Brand name: Zoryve
Dosage form: topical cream (0.3%)
Drug class: Selective phosphodiesterase-4 inhibitors

Medically reviewed by Drugs.com on Nov 28, 2023. Written by Cerner Multum.

What is roflumilast topical?

Roflumilast topical (for the skin) is used to treat plaque psoriasis in adults and children at least 6 years old.

Roflumilast topical may also be used for purposes not listed in this medication guide.

Roflumilast topical side effects

Get emergency medical help if you have signs of an allergic reaction: hives, difficult breathing, swelling of your face, lips, tongue, or throat.

Common side effects of roflumilast topical may include:

• diarrhea, nausea;

• pain at site of application;

• sleep problems (insomnia);

• pain and burning when you urinate;

• headache; or

• cold symptoms such as stuffy nose, sneezing, sore throat.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Warnings

Use only as directed. Tell your doctor if you use other medicines or have other medical conditions or allergies.

Before taking this medicine

You should not use roflumilast topical if you have:

• liver problems.

It is not known if roflumilast topical will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

Ask a doctor if it is safe to breastfeed while using roflumilast topical.

If you breastfeed, avoid applying this medicine to your nipple area.

How should I use roflumilast topical?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Roflumilast topical is applied once per day. Follow your doctor's instructions.

Do not use in your mouth, eyes, or genitals. Topical medicine is for use only on the skin.

Wash your hands before and after applying this medicine, unless you are using it to treat a hand condition.

Use only a small amount of medicine. Apply a thin layer and rub in gently.

Store at room temperature away from moisture and heat.

Roflumilast topical dosing information

Usual Adult Dose for Plaque Psoriasis:

Apply topically to the affected areas once a day

Comments:
-Not intended for ophthalmic, oral, or intravaginal use.

Use: Topical treatment of plaque psoriasis

Usual Pediatric Dose for Plaque Psoriasis:

12 to less than 18 years: Apply topically to the affected areas once a day

Comments:
-Not intended for ophthalmic, oral, or intravaginal use.

Use: Topical treatment of plaque psoriasis

What happens if I miss a dose?

Apply the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not apply two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222 if anyone has accidentally swallowed the medicine.

What should I avoid while using roflumilast topical?

Avoid using roflumilast topical on unaffected areas of the skin.

What other drugs will affect roflumilast topical?

Sometimes it is not safe to use certain medicines at the same time. Some drugs can affect your blood levels of other drugs you use, which may increase side effects or make the medicines less effective.

Tell your doctor about all your other medicines, especially:

• birth control pills and other hormones.

This list is not complete and many other drugs may affect roflumilast topical. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

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